Transmission electron microscopy may aid in the diagnosis of routine surgical cases. By examining the ultra-structure of tissues we can define the morphological aspects of disease processes, aiding diagnosis. In addition, as a University teaching hospital, research projects are undertaken and many cases are received as referrals from across the North.
Seventy five per cent of cases are renal biopsies where visualisation of specific ultrastructural features is often of great prognostic value. Other tissues routinely prepared and screened include GI, lung, skin, brain, heart and nerves.
Preparation of material is highly skilled requiring dexterity and patience to produce quality ultra-sections (100-120nm)with interpretive screening being undertaken by experienced Biomedical Scientists, often in conjunction with Medical Consultants.